Anti-epileptic drugs (AEDs) are usually the first choice of treatment for epilepsy. About 70% of people with the condition are able to control their seizures with AEDs.
Usually, AED treatment will not begin until after you have had a second seizure because a single seizure is not necessarily a reliable indicator that you have epilepsy.
Most people with epilepsy can be successfully treated with AEDs.
AEDs do not cure epilepsy, but can prevent seizures from occurring.
There are many different AEDs. Generally, they work by changing the levels of the chemicals in your brain that conduct electrical impulses.
This reduces the chance of a seizure.

The type of AED recommended for you will depend on a number of factors, including the type of seizures you have, your age, whether there are any concerns about a certain AED interacting with other medicines (such as the contraceptive pill), and whether you are thinking of having a baby.
Examples of commonly used AEDs include Sodium Valproate, Carbamazepine, Lamotrigine, Levetiracetam, Oxcarbazepine, Topiramate and Keppra.

Taking AEDs

AEDs are available in a number of different forms, including tablets, capsules, liquids and syrups.
It is important you follow any advice about when to take AEDs and how much to take. Never suddenly stop taking an AED because doing so could cause a seizure.
Your specialist will start you on a low dose of an AED, then gradually increase it within safe limits until your seizures stop, or if you develop side-effects. If one AED does not control seizures, another will be tried by gradually introducing the new medication and slowly reducing the dose of the old one.

The aim is to achieve maximum seizure control with minimum side effects, using the lowest possible dose of a single medicine. Trying a different type of AED is preferable to taking more than one AED, although a combination of medicines may sometimes be necessary to control seizures.

While taking AEDs, do not take any other medicines, including over-the-counter medicines or complementary medicines such as St John's Wort, without first speaking to your GP or epilepsy specialist. Other medicines could have a dangerous interaction with your AED and cause a seizure.

Sodium valproate is not usually prescribed for women of childbearing age because there is a risk it could cause physical defects or developmental problems in an unborn baby.
It can be used if there is no alternative, or if your specialist has assessed you and it's unlikely you'll respond to or tolerate other treatments. Your specialist or GP will also need to check you are using a reliable form of contraception. 

If you do not have a seizure for more than two years, it may be possible to stop taking your AEDs. Your epilepsy specialist can discuss with you whether this is appropriate and the best way this can be done.
Side effects
Side effects are common when starting treatment with AEDs. However, they are usually short-lived and pass in a few days.
The specific side effects that you may experience will depend on the medication you are taking, but general common side effects of AEDs include:

  • drowsiness
  • a lack of energy
  • agitation
  • headache
  • uncontrollable shaking
  • hair loss or unwanted hair growth
  • swollen gums
  • rashes

If you develop a rash, this may mean that you are allergic to the medication.
In this case seek medical advice right away. Sometimes, you may experience symptoms similar to being drunk – such as unsteadiness, poor concentration and vomiting – if your dose is too high. Contact your GP or epilepsy specialist immediately if you experience these side effects so that your dose can be revised. For information on the side effects of a particular AED, check the information leaflet that comes with your medication.